---
kind: "section"
citation: "21 C.F.R. § 573.302"
title: "21"
number: "573.302"
heading: "Chromium DL-methionine chelate."
url: "https://uscodex.org/cfr/21/573.302"
---

# §573.302. Chromium DL-methionine chelate.


The food additive, chromium DL-methionine chelate may be safely used as a nutritional source of chromium in cattle feed in accordance with the following prescribed conditions:

- (a) The additive is manufactured by the reaction of a chromium salt with excess DL-methionine, at an appropriate stoichiometric ratio, to produce a chelate, tris (DL-methioninato) chromium (III) hydrochloride, and with the empirical formula Cr[(CH3S(CH2)2CH(NH2)COO)3]·HCl.
- (b) The additive is added to complete feed for cattle at a level not to exceed 0.5 milligrams (mg) of chromium from chromium DL-methionine chelate per kilogram (kg) feed.
- (c) **The additive meets the following specifications—**
  - (1) **Total chromium content, 5 to 6 percent.**
  - (2) **Chelated chromium content, not less than 98 percent of the total chromium.**
  - (3) **Total DL-Methionine content, 80 to 85 percent.**
  - (4) **Hexavalent chromium content, less than 20 parts per million (ppm).**
  - (5) Arsenic, less than 0.1 ppm.
  - (6) Cadmium, less than 0.05 ppm.
  - (7) Lead, less than 0.1 ppm.
  - (8) Mercury, less than 0.05 ppm.
- (d) The additive shall be incorporated into feed as follows:
  - (1) It shall be incorporated into each ton of complete feed by adding no less than one pound of a premix containing no more than 453.6 milligrams of added chromium from chromium DL-methionine chelate per pound.
  - (2) Chromium from all sources of supplemental chromium cannot exceed a level of 0.5 ppm in complete feed for cattle.
- (e) To assure safe use of the additive in addition to the other information required by the Federal Food, Drug, and Cosmetic Act:
  - (1) The label and labeling of the additive, any feed premix, and feed shall contain the name of the additive.
  - (2) The label and labeling of the additive and any feed premix shall also contain:
    - (i) **Minimum and maximum guarantees for added chromium content.**
    - (ii) **Adequate directions for use and cautions for use including this statement—** “Caution: Follow label directions” and, consistent with the directions for use, the following: “Chromium from all sources of supplemental chromium cannot exceed 0.5 parts per million intake of the complete feed for cattle.”
    - (iii) **Appropriate warnings and safety precautions concerning the chromium DL-methionine chelate.**

## Notes

### Amendments

[91 FR 53526, Aug. 19, 2026]

### Authority

Authority: 21 U.S.C. 321, 342, 348.

### Source

Source: 41 FR 38652, Sept. 10, 1976, unless otherwise noted.

### Amendments

[91 FR 53526, Aug. 19, 2026]