---
kind: "section"
citation: "21 C.F.R. § 524.1146"
title: "21"
number: "524.1146"
heading: "Imidacloprid and moxidectin."
url: "https://uscodex.org/cfr/21/524.1146"
---

# §524.1146. Imidacloprid and moxidectin.

- (a) **Specifications.** Each milliliter of solution contains:
  - (1) 100 milligrams (mg) imidacloprid and 25 mg moxidectin; or
  - (2) 100 mg imidacloprid and 10 mg moxidectin.
- (b) **Sponsors.** See sponsor numbers in [§ 510.600(c)](/cfr/21/510.600.md?p=c) of this chapter as follows:
  - (1) **Nos.** 017030, 051072, 051311, 055529, 058198, and 061133for use of product described in [paragraph (a)(1)](#a-1) of this section as in [paragraph (d)(1)](#d-1) of this section.
  - (2) **Nos.** 017030, 051072, 051311, 055529, 058198, and 061133 for use of product described in [paragraph (a)(2)](#a-2) of this section as in [paragraph (d)(2)](#d-2) of this section.
  - (3) **Nos.** 051072, 055529, 058198, 061133, and 061651 for use of product described in [paragraph (a)(2)](#a-2) of this section as in [paragraph (d)(3)](#d-3) of this section.
- (c) **Special considerations.** Federal law restricts this drug to use by or on the order of a licensed veterinarian.
- (d) **Conditions of use—**
  - (1) **Dogs—**
    - (i) **Amount.** Topically apply 4.5 mg/lb body weight (10 mg/kg) imidacloprid and 1.1 mg/lb (2.5 mg/kg) moxidectin, once a month.
    - (ii) **Indications for use.**
      - (A) For the prevention of heartworm disease caused by Dirofilaria immitis; and the treatment and control of intestinal roundworms (Toxocara canis and Toxascaris leonina), hookworms (Ancylostoma caninum and Uncinaria stenocephala), and whipworms (Trichuris vulpis); kills adult fleas and treats flea infestations (Ctenocephalides felis).
      - (B) For treatment of Dirofilaria immitis circulating microfilariae in heartworm-positive dogs and the treatment and control of sarcoptic mange caused by Sarcoptes scabiei var. canis.
  - (2) **Cats—**
    - (i) **Amount.** Topically apply 4.5 mg/lb body weight (10 mg/kg) imidacloprid and 0.45 mg/lb (1.0 mg/kg) moxidectin, once a month.
    - (ii) **Indications for use.** For the prevention of heartworm disease caused by Dirofilaria immitis; for the treatment and control of ear mite (Otodectes cynotis) infestations, intestinal roundworms (Toxocara cati), and hookworms (Ancylostoma tubaeforme); kills adult fleas and treats flea infestations (Ctenocephalides felis).
  - (3) **Ferrets—**
    - (i) **Amount.** Topically apply 9.0 mg/lb body weight (20 mg/kg) imidacloprid and 0.9 mg/lb (2 mg/kg) moxidectin, once a month.
    - (ii) **Indications for use.** For the prevention of heartworm disease caused by Dirofilaria immitis; kills adult fleas (Ctenocephalides felis) and is indicated for the treatment of flea infestations on ferrets.

## Notes

### Amendments

[72 FR 10597, Mar. 9, 2007, as amended at 78 FR 73698, Dec. 9, 2013; 85 FR 18120, Apr. 1, 2020; 86 FR 13185, Mar. 8, 2021; 86 FR 14821, Mar. 19, 2021; 87 FR 17946, Mar. 29, 2022; 87 FR 58963, Sept. 29, 2022; 88 FR 27700, May 3, 2023; 89 FR 14410, Feb. 27, 2024; 90 FR 40970, Aug. 22, 2025]

### Authority

Authority: 21 U.S.C. 360b.

### Source

Source: 40 FR 13873, Mar. 27, 1975, unless otherwise noted.

### Amendments

[72 FR 10597, Mar. 9, 2007, as amended at 78 FR 73698, Dec. 9, 2013; 85 FR 18120, Apr. 1, 2020; 86 FR 13185, Mar. 8, 2021; 86 FR 14821, Mar. 19, 2021; 87 FR 17946, Mar. 29, 2022; 87 FR 58963, Sept. 29, 2022; 88 FR 27700, May 3, 2023; 89 FR 14410, Feb. 27, 2024; 90 FR 40970, Aug. 22, 2025]