---
kind: "section"
citation: "21 C.F.R. § 349.30"
title: "21"
number: "349.30"
heading: "Permitted combinations of active ingredients."
url: "https://uscodex.org/cfr/21/349.30"
---

# §349.30. Permitted combinations of active ingredients.


The following combinations are permitted provided each active ingredient is present within the established concentration, and the product is labeled in accordance with [§ 349.79](/cfr/21/349.79.md).

- (a) Any single ophthalmic astringent active ingredient identified in [§ 349.10](/cfr/21/349.10.md) may be combined with any single ophthalmic vasoconstrictor active ingredient identified in [§ 349.18](/cfr/21/349.18.md).
- (b) Any two or three ophthalmic demulcent active ingredients identified in [§ 349.12](/cfr/21/349.12.md) may be combined.
- (c) Any single ophthalmic demulcent active ingredient identified in [§ 349.12](/cfr/21/349.12.md) or any ophthalmic demulcent combination identified in [paragraph (b)](#b) of this section may be combined with any single ophthalmic vasoconstrictor identified in [§ 349.18](/cfr/21/349.18.md).
- (d) Any single ophthalmic astringent active ingredient identified in [§ 349.10](/cfr/21/349.10.md) may be combined with any single ophthalmic vasoconstrictor active ingredient identified in [§ 349.18](/cfr/21/349.18.md) and any single ophthalmic demulcent identified in [§ 349.12](/cfr/21/349.12.md) or ophthalmic demulcent combination identified in [paragraph (b)](#b) of this section.
- (e) Any two or more emollient active ingredients identified in [§ 349.14](/cfr/21/349.14.md) may be combined as necessary to give the product proper consistency for application to the eye.

## Notes

### Authority

Authority: 21 U.S.C. 321, 351, 352, 353, 355, 360, 371.

### Source

Source: 53 FR 7090, Mar. 4, 1988, unless otherwise noted.